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You’re committed to
managing your diabetes.

Lilly is committed to
ensuring you can afford
your Lilly insulin.

That's why we offer a portfolio of lower list-priced* insulins.

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Call The Lilly Answers Center
Call: 1-800-LillyRx (1-800-545-5979)

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Patient Image

You’re committed to managing your diabetes.

Lilly is committed to ensuring you can afford your Lilly insulin.

That's why we offer a portfolio of lower list-priced* insulins.

learn more

Insulin Lispro Injection U-100

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Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25™ KwikPen®

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Insulin Lispro Injection Junior KwikPen®

Lilly's portfolio of non-branded insulins may help to reduce your out-of-pocket costs*

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When you pick up your prescription, your pharmacist can help determine your least expensive option.

*Important: For many people with commercial drug insurance, Lilly's Humalog branded insulin may still have a lower out-of-pocket cost than Lilly's non-branded insulins.

*You should consider formulary status of all medications you may be taking when making enrollment decisions.

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If you are struggling to afford the medication or diabetes care you need, please call the Lilly Diabetes Solution Center at 1-833-808-1234.

Learn about pricing

insulin-logo insulin-logo

The same insulin as Humalog® U-100 to help control blood sugar spikes that can happen after a meal.

  • Same insulin as Humalog U-100 available under a different label in the same KwikPen and vial made by the same manufacturer.

plus Learn more about this insulin

Vial and Pen

Humalog and Insulin Lispro Injection are used to treat people with diabetes for the control of high blood sugar.

Select Safety Information
Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have symptoms of low blood sugar (hypoglycemia) or an allergy to insulin lispro products or any of their ingredients.

Humalog U100 Kwikpen Logo

insulin-logo insulin-logo

The same insulin as Humalog® Mix75/25™ to help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

  • Same insulin as Humalog Mix75/25 available under a different label in the same KwikPen made by the same manufacturer.
  • Same KwikPen

plus Learn more about this insulin

Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are used to treat adults with diabetes for the control of high blood sugar.

Vial and Pen

Select Safety Information

Do not reuse needles or share your insulin injection supplies with other people. This includes your

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Humalog Mix75/25 Logo

insulin-logo insulin-logo

The insulin in the Insulin Lispro Injection Junior KwikPen works just like the insulin in the Humalog Junior KwikPen. This insulin helps control blood sugar "spikes" that happen after you eat.

  • Same insulin as Humalog Junior KwikPen available under a different label in the same KwikPen made by the same manufacturer.
  • Same KwikPen

plus Learn more about this product

Humalog Junior Kwikpen Logo

Vial and Pen

See all the ways Lilly may be able to help you save
money on your insulin.

insulin affordability

PURPOSE and SAFETY SUMMARY

Important Facts About Humalog® (HU-ma-log) and Insulin Lispro Injection

  • Humalog is also known as insulin lispro injection. 
  • Humalog and Insulin Lispro Injection are fast-acting insulins. They are used to control high blood sugar in adults and children with diabetes. They are available only with a prescription.
  • Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.  
  • It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Important Facts about Humalog® Mix50/50, Humalog® Mix75/25™, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25

  • Humalog Mix50/50 and Humalog Mix75/25 are known as insulin lispro protamine and insulin lispro injectable suspension.
  • Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixed U-100 insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes. They are available only with a prescription.
  • It is not known if Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are safe and effective for children younger than 18 years of age. There were no studies done with these insulins in children younger than 18. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

All Humalog and Insulin Lispro Injection products contain insulin lispro.  Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 contain insulin lispro protamine mixed with insulin lispro.

Warnings
Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro products or any of their ingredients.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle. 

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. 

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • Low blood sugar. This can cause:
    • dizziness or light-headedness
    • headache
    • shakiness
    • irritability
    • sweating
    • blurred vision
    • fast heartbeat
    • mood change
    • confusion
    • slurred speech
    • anxiety
    • hunger

If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.

  • Severe allergic reaction. Get emergency help right away if you have:
    • a rash over your whole body
    • sweating
    • extreme drowsiness
    • swelling of your face, tongue, or throat
    • trouble breathing
    • a faint feeling
    • dizziness
    • a fast heartbeat
    • shortness of breath
    • confusion
  • Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
  • Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or “TZDs,” with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
  • High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Common side effects

The most common side effects of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are:

  • low blood sugar
  • reactions where you have injected insulin
  • swelling of your hands or feet
  • itching
  • allergic reactions
  • changes in fat tissue where you have injected insulin
  • weight gain
  • rash

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

  • about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
  • about any other prescription medicines you take, especially ones called TZDs.
  • about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
  • if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your insulin lispro product

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

  • Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
  • Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
  • Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

  • If you are taking Humalog or Insulin Lispro Injection, inject it under your skin within 15 minutes before or right after you eat a meal.
  • If you are taking Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, inject it under your skin within 15 minutes before you eat a meal.

Staying safe while taking your insulin lispro product

To stay safe while taking your insulin, be sure to never inject Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 in your vein, muscle, or with an insulin pump.  Also be sure not to:

  • mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids. 
  • drive or use heavy machinery until you know how your insulin lispro product affects you. 
  • drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product.

Learn more

For more information, call 1-800-545-5979 or go to www.humalog.com or www.lillyinsulinlispro.com.

This summary provides basic information about Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

For additional information, talk to your healthcare providers and please click to access Humalog  Full Prescribing Information, Humalog U-100  Patient Prescribing Information, Humalog U-200  Patient Prescribing Information, Humalog Mix75/25  Full Prescribing Information, Humalog Mix75/25  Patient Prescribing Information, Humalog Mix50/50  Full Prescribing Information, Humalog Mix50/50  Patient Prescribing Information, Insulin Lispro Injection Full Prescribing Information, and Insulin Lispro Injection  Patient Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Full Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Patient Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen Instructions for Use, Insulin Lispro Injection Junior KwikPen Instructions for Use.

Please see  Humalog U-100 KwikPen Instructions for Use, Humalog Junior KwikPen Instructions for Use, Humalog U-100 Vial Instructions for Use, Humalog Mix75/25 KwikPen Instructions for Use, Insulin Lispro Injection KwikPen Instructions for Use, and Insulin Lispro Injection Vial Instructions for Use included with your medication.

HI BOI SP U100 75/25 CON BS 10JAN2020

Humalog®, KwikPen®, Humalog® Junior KwikPen®, Humalog® Mix75/25TM, and Humalog® Mix50/50TM are trademarks and registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only. 

PURPOSE and SAFETY SUMMARY

Read More

Important Facts About Humalog® (HU-ma-log) and Insulin Lispro Injection

  • Humalog is also known as insulin lispro injection. 
  • Humalog and Insulin Lispro Injection are fast-acting insulins. They are used to control high blood sugar in adults and children with diabetes. They are available only with a prescription.
  • Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.  
  • It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Important Facts about Humalog® Mix50/50, Humalog® Mix75/25™, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25

  • Humalog Mix50/50 and Humalog Mix75/25 are known as insulin lispro protamine and insulin lispro injectable suspension.
  • Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixed U-100 insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes. They are available only with a prescription.
  • It is not known if Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are safe and effective for children younger than 18 years of age. There were no studies done with these insulins in children younger than 18. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

All Humalog and Insulin Lispro Injection products contain insulin lispro.  Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 contain insulin lispro protamine mixed with insulin lispro.

Warnings
Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro products or any of their ingredients.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle. 

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. 

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • Low blood sugar. This can cause:
    • dizziness or light-headedness
    • headache
    • shakiness
    • irritability
    • sweating
    • blurred vision
    • fast heartbeat
    • mood change
    • confusion
    • slurred speech
    • anxiety
    • hunger

If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.

  • Severe allergic reaction. Get emergency help right away if you have:
    • a rash over your whole body
    • sweating
    • extreme drowsiness
    • swelling of your face, tongue, or throat
    • trouble breathing
    • a faint feeling
    • dizziness
    • a fast heartbeat
    • shortness of breath
    • confusion
  • Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
  • Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or “TZDs,” with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
  • High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Common side effects

The most common side effects of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are:

  • low blood sugar
  • reactions where you have injected insulin
  • swelling of your hands or feet
  • itching
  • allergic reactions
  • changes in fat tissue where you have injected insulin
  • weight gain
  • rash

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

  • about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
  • about any other prescription medicines you take, especially ones called TZDs.
  • about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
  • if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your insulin lispro product

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

  • Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
  • Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
  • Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

  • If you are taking Humalog or Insulin Lispro Injection, inject it under your skin within 15 minutes before or right after you eat a meal.
  • If you are taking Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, inject it under your skin within 15 minutes before you eat a meal.

Staying safe while taking your insulin lispro product

To stay safe while taking your insulin, be sure to never inject Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 in your vein, muscle, or with an insulin pump.  Also be sure not to:

  • mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids. 
  • drive or use heavy machinery until you know how your insulin lispro product affects you. 
  • drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product.

Learn more

For more information, call 1-800-545-5979 or go to www.humalog.com or www.lillyinsulinlispro.com.

This summary provides basic information about Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

For additional information talk to your healthcare providers and please click to access Humalog  Full Prescribing Information, Humalog U-100  Patient Prescribing Information, Humalog U-200  Patient Prescribing Information, Humalog Mix75/25  Full Prescribing Information, Humalog Mix75/25  Patient Prescribing Information, Humalog Mix50/50  Full Prescribing Information, Humalog Mix50/50  Patient Prescribing Information, Insulin Lispro Injection Full Prescribing Information, and Insulin Lispro Injection  Patient Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Full Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Patient Prescribing Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen Instructions for Use, Insulin Lispro Injection Junior KwikPen Instructions for Use.

Please see  Humalog U-100 KwikPen Instructions for Use, Humalog Junior KwikPen Instructions for Use, Humalog U-100 Vial Instructions for Use, Humalog Mix75/25 KwikPen Instructions for Use, Insulin Lispro Injection KwikPen Instructions for Use, and Insulin Lispro Injection Vial Instructions for Use included with your medication.

HI BOI SP U100 75/25 CON BS 10JAN2020

Humalog®, KwikPen®, Humalog® Junior KwikPen®, Humalog® Mix75/25TM, and Humalog® Mix50/50TM are trademarks and registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.