Insulin Affordability Update
Do you have patients who would benefit from Lilly's Non-Branded Insulins?
Consider Lilly's Portfolio of Non-Branded Insulins for patients who face high out-of-pocket costs* for their Humalog-branded insulin.
*Note that for many people with commercial drug insurance, Lilly's branded insulins may still have a lower out-of-pocket cost than Lilly's Non-Branded Insulins.†
†Out-of-pocket costs may vary depending on a patient’s plan. Please contact plan administrator for most current information.

Click here for a bilingual brochure that you can use to provide information about Insulin Lispro to your English and Spanish-speaking patients.
Humalog (insulin lispro injection, 100 units/mL) and Insulin Lispro Injection (100 units/mL) are indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog Mix75/25 (insulin lispro protamine and insulin lispro injectable suspension, 100 units/mL) and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 (100 units/mL) are indicated to improve glycemic control in patients with diabetes mellitus.
Limitations of Use: The proportions of rapid-acting and intermediate-acting insulins in Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are fixed and do not allow for basal versus prandial dose adjustments.
These non-branded insulin lispro products feature the same molecule as the Humalog-branded insulin products you are familiar with.
- Same safety and efficacy profile
- Same manufacturer
- Same KwikPen® and vial‡
Continue to write the Humalog-branded product.
Pharmacists can determine the most affordable Lilly insulin option for your patients.¶
Select Safety Information
Humalog, Insulin Lispro Injection, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to these insulins or any of their excipients.
All of Lilly's Non-Branded Insulins are available in a KwikPen, which is a small lightweight, prefilled insulin pen for patients with diabetes who want a portable device.
For proper administration, pharmacists should engage patients and caregivers to discuss the Instructions for Use for these insulins.
Note that for many people with commercial drug insurance, Lilly's branded insulins may still have a lower out-of-pocket cost than Lilly's Non-Branded Insulins.¶ Pharmacists, please see the information below about “Steps to ensure Humalog patients get the most affordable Lilly insulin option.”
‡Vials are available only for Lilly’s Insulin Lispro Injection U-100.
¶Out-of-pocket costs may vary depending on a patient’s plan. Please contact plan administrator for most current information.

Branded Name
|
Non-branded Name
|
---|---|
Branded Name Humalog® U-100 | Non-branded Name Insulin Lispro Injection U-100 |
Branded Name Humalog® Mix75/25™ | Non-branded Name Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen |
Branded Name Humalog® Junior KwikPen® | Non-branded Name Insulin Lispro Injection Junior KwikPen |
How to stock and order
Sales Package Information and Specifications
Sales Package Size
|
NDC and UPC
|
Wholesale Acquisition Cost (WAC)*
|
---|---|---|
Sales Package Size INSULIN LISPRO INJECTION KWIKPEN 100 U/ML 3 ML X 5 | NDC and UPC NDC: 0002-8222-59 UPC: 3-0002-8222-59-1 | Wholesale Acquisition Cost (WAC)* $159.12* |
Sales Package Size INSULIN LISPRO INJECTION 100 U/ML 10 ML X 1 VIAL | NDC and UPC NDC: 0002-7737-01 UPC: 3-0002-7737-01-0 | Wholesale Acquisition Cost (WAC)* $25.00* |
Sales Package Size INSULIN LISPRO PROTAMINE AND INSULIN LISPRO INJECTABLE SUSPENSION MIX75/25 KWIKPEN | NDC and UPC NDC: 0002-8233-05 UPC: 3-00028-233-05-4 | Wholesale Acquisition Cost (WAC)* $159.12* |
Sales Package Size INSULIN LISPRO INJECTION JUNIOR KWIKPEN 100 U/ML 3 ML X 5 | NDC and UPC NDC: 0002-7752-05 UPC: 3-0002-7752-05-1 | Wholesale Acquisition Cost (WAC)* $159.12* |
*The Lilly WAC is the listed price to the distribution channel not including prompt pay, service or administrative fees, stocking or distribution allowances, or any discounts, rebates, or chargebacks provided by Lilly USA, LLC to any entity.
Product
|
Carton Dimensions (L x W x H) (inches)
|
Carton Weight (ounces)
|
Cartons Per Case
|
Case Dimensions (L x W x H) (inches)
|
Case Weight (pounds)
|
Case Per Pallet
|
---|---|---|---|---|---|---|
Product INSULIN LISPRO INJECTION KWIKPEN 100 U/ML 3 ML X 5 | Carton Dimensions (L x W x H) (inches) 3.6 x 1.1 x 5.8 | Carton Weight (ounces) 6.72 | Cartons Per Case 36 | Case Dimensions (L x W x H) (inches) 15.1 x 11.1 x 6.6 | Case Weight (pounds) 16.24 | Case Per Pallet 77 |
Product INSULIN LISPRO INJECTION 100 U/ML 10 ML X 1 VIAL | Carton Dimensions (L x W x H) (inches) 1.8 x 1.5 x 2.6 | Carton Weight (ounces) 1.25 | Cartons Per Case 100 | Case Dimensions (L x W x H) (inches) 18.8 x 8.2 x 5.9 | Case Weight (pounds) 8.5 | Case Per Pallet 70 |
Product INSULIN LISPRO PROTAMINE AND INSULIN LISPRO INJECTABLE SUSPENSION MIX75/25™ KWIKPEN | Carton Dimensions (L x W x H) (inches) 3.6 x 1.1 x 5.8 | Carton Weight (ounces) 6.72 | Cartons Per Case 36 | Case Dimensions (L x W x H) (inches) 15.1 x 11.1 x 6.6 | Case Weight (pounds) 16.24 | Case Per Pallet 77 |
Product INSULIN LISPRO INJECTION JUNIOR KWIKPEN 100 U/ML 3 ML X 5 | Carton Dimensions (L x W x H) (inches) 3.6 x 1.1 x 5.8 | Carton Weight (ounces) 6.6 | Cartons Per Case 36 | Case Dimensions (L x W x H) (inches) 15.1 x 11.1 x 6.6 | Case Weight (pounds) 16.24 | Case Per Pallet 77 |
Minimum Order Quantity: 1 carton of 5 KwikPens or 100 vials
Billing Quantity: 15 mL per 5-pen pack or 10 mL per vial
Prescription Legend: Yes
Returned Goods: Please visit www.lillytrade.com for further details.
Distribution: Lilly USA Authorized Distributors of Record
Storage: Refrigeration is required during storage and handling (36°F to 46°F [2°C to 8°C]). Patients may store Insulin Lispro Injection at room temperature (below 86°F [30°C]) up to 28 days. Patients may store Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 at room temperature (Below 86°F [30°C]) up to 10 days. For any questions regarding storage and handling, call 1-800-LillyRx ( 1-800-545-5979 ).
TAA Compliant: Yes
Country of Origin: USA
Steps to ensure Humalog patients get the most affordable Lilly insulin option:
How to compare out-of-pocket cost (KwikPen example):
Take two substitutable medicines (example: Humalog and Insulin Lispro Injection).
Run the NDC for each – Humalog U-100 KwikPen 0002-8799-59 and Lilly’s Insulin Lispro Injection KwikPen 0002-8222-59.
Dispense the Lilly insulin that offers your patient the lower out-of-pocket cost and inform them if a substitution was made.

The Lilly Diabetes Solution Center may be able to help patients who need additional assistance paying for medications or care. Encourage your patients to call the Lilly Diabetes Solution Center at 1-833-808-1234.
Prescribing Information
Insulin Lispro Injection Prescribing Information
Insulin Lispro Injection Patient Information
Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Prescribing Information
Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Patient Information
INDICATIONS
Humalog and Insulin Lispro Injection are indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixtures of intermediate-acting and rapid-acting insulin analogs indicated to improve glycemic control in patients with diabetes mellitus.
Limitations of Use: The proportions of rapid-acting and intermediate-acting insulins in Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are fixed and do not allow for basal versus prandial dose adjustments.