What to Know About Lilly’s Insulin Lispro

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What to Know About Lilly’s Insulin Lispro

Lilly's Insulin Lispro is a fast-acting mealtime insulin

Because it’s identical to Humalog® (insulin lispro), Lilly’s Insulin Lispro helps control the blood sugar spikes that happen naturally when you eat. As you eat, your blood sugar naturally goes up, or “spikes.” Lilly’s Insulin Lispro (a fast-acting insulin) works to manage those blood sugar spikes and may help keep your blood sugar levels in balance. Lilly’s Insulin Lispro should be taken within 15 minutes before eating or right after eating a meal. Humalog is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day.


How to use Lilly’s Insulin Lispro KwikPen®

The Insulin Lispro KwikPen is a small, lightweight pen that’s prefilled with mealtime insulin. Since it shouldn’t be refrigerated* after the first use, you can take it just about anywhere. You can carry it in a purse or slip it into a jacket or coat pocket. It’s a good idea to always carry an extra pen.

For complete Instructions for Use of the Insulin Lispro KwikPen, download the following PDF.

*Once you start using Insulin Lispro KwikPen, it should be stored at room temperature, below 86F (30C), and must be used within 28 days or be discarded, even if it still contains Insulin Lispro.


Where to inject Lilly’s Insulin Lispro

Lilly’s Insulin Lispro may be injected under your skin in the stomach area or the back of your upper arms, upper legs, or buttocks (see diagram). Never inject Lilly’s Insulin Lispro into a muscle or vein. Ask your doctor for help determining the most appropriate injection sites for you.

injection site

Try to use a different injection site each time and do not overuse any site. Reactions at the injection site (local allergic reactions) such as redness, swelling, and itching can happen. If you continually have skin reactions or they are serious, talk to your doctor. Do not inject insulin into red, swollen, or itchy skin.

Severe life-threatening allergic reactions (whole-body reactions) are possible. If you develop a whole-body rash, have trouble breathing, have a fast heartbeat, or are sweating, get medical help right away.


What to expect with Lilly’s Insulin Lispro

Everyone’s experience with mealtime insulin is different, but there are some things you can look out for.

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Dose changes

Your Lilly’s Insulin Lispro dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their dose over time.

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Blood sugar variations

When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal.

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Changes are normal

Your blood sugar varies based on stress, what you eat, other medications, exercise, and other factors. Don’t be discouraged by changes in your blood sugar. With your doctor’s input, these variations may provide learning opportunities.

Who should use Humalog and Insulin Lispro?

Humalog and Insulin Lispro are used to treat people with diabetes for the control of high blood sugar.

Who should not take Humalog and Insulin Lispro?

Do not take Humalog or Insulin Lispro if your blood sugar is too low (hypoglycemia) or if you are allergic to Humalog or Insulin Lispro or any of the ingredients in Humalog or Insulin Lispro.

Important Safety Information for Humalog® (insulin lispro) and Insulin Lispro

What is the most important information I should know about Humalog and Insulin Lispro?

  • Do not share your Humalog or Insulin Lispro KwikPen or syringe with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Test your blood sugar levels as your healthcare provider instructs.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog or Insulin Lispro with any other insulin or liquid.

Who should not take Humalog and Insulin Lispro?

  • Do not take Humalog or Insulin Lispro if your blood sugar is too low (hypoglycemia) or if you are allergic to Humalog or Insulin Lispro or any of the ingredients in Humalog or Insulin Lispro.

Before using Humalog or Insulin Lispro, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart failure or other heart problems.
  • If you are pregnant, planning to become pregnant, or are breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog or Insulin Lispro?

  • Humalog and Insulin Lispro are rapid-acting insulins. Take Humalog or Insulin Lispro within fifteen minutes before eating or right after eating a meal.
  • Always make sure you receive the correct type of Humalog or Insulin Lispro from the pharmacy.
  • Do not use Humalog or Insulin Lispro if it is cloudy, colored, or has solid particles or clumps in it.
  • Inject Humalog or Insulin Lispro under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to receive the wrong dose of Humalog or Insulin Lispro and result in infection.
  • Do not drive or operate heavy machinery until you know how Humalog or Insulin Lispro affects you. Do not use alcohol while using Humalog or Insulin Lispro.

What are the possible side effects of Humalog or Insulin Lispro?

  • Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much Humalog or Insulin Lispro. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Humalog or Insulin Lispro can cause life-threatening low potassium in your blood (hypokalemia), which can cause severe breathing problems, irregular heartbeat, and death.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog or Insulin Lispro. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs or Humalog or Insulin Lispro.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog or Insulin Lispro include low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash. These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Humalog and Insulin Lispro are available by prescription only.

For additional information, talk to your healthcare providers and please click to access Humalog Full Prescribing Information and Patient Prescribing Information.

For additional information, talk to your healthcare providers and please click to access Insulin Lispro Full Prescribing Information and Patient Prescribing Information.

Please click to access Instructions for Use for Humalog vial and Humalog KwikPen. Please click to access Instructions for Use for Insulin Lispro vial and Insulin Lispro KwikPen.

HI IL CON ISI 04MAR2019.

Humalog® and KwikPen® are registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.